Pyridoxal-5′-phosphate (PLP or P5P) is the biologically active form of vitamin B6 that is actually utilized by the body. Vitamin B6 is most commonly known as pyridoxine, but in fact B6 is comprised of three organic forms, namely pyridoxal, pyridoxine, and pyridoxamine. The three differ from each other slightly in their respective biochemical structures, but each represents a different stage in the body’s metabolism of this important vitamin. P5P represents the advanced stage of this metabolism, the stage at which B6 has been converted into a coenzyme, a catalyst for at least 113 known essential enzymatic reactions in the body.Anyone taking regular B6 should consider switching to P-5-P for enhanced absorption and effectiveness. P-5-P is essential for those with liver disorders, mood disorders, autism or anyone diagnosed with compromised B6 metabolism. P-5-P supports immune function in those who are critically ill, and pregnant women may benefit from the anti-nausea effects of vitamin B6.